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WHOLE TISSUE IMAGING AND ANALYSIS

About TissueMetrics

3D TISSUE AND WHOLE ORGAN IMAGING STUDIES TO DEVELOP NEW THERAPEUTICS FOR DISEASES.

We specialize in contract research for whole organ and tissue imaging and analysis. 

TissueMetrics is a contract research organization that works with researchers and companies to perform 3D tissue and whole organ imaging studies to help develop new therapeutics for diseases.

 

We are capable of handling entire studies from animal husbandry through tissue labeling and image analysis. Customers can also prepare samples on their own and send us fixed tissues, which we will image and perform any desired analyses.

Many of our studies are conducted on our TissueCyte™ platforms, which produces consistent, high-fidelity 3D multi-color images of whole organs and tissues that lend themselves well to quantitative analysis. The high throughput nature of our imaging pipeline makes it possible to conduct studies involving tens to hundreds of samples, delivering results with high statistical power and biomedical relevance.  Moreover, our process is non-destructive and produces high quality tissue sections that can be used for secondary analysis to investigating underlying biomolecular signatures. 

The technologies behind these services have shown proven results and have been profiled in multiple high throughput studies and publications:


 

  • Oh, Seung Wook, Julie A. Harris, Lydia Ng, Brent Winslow, Nicholas Cain, Stefan Mihalas, Quanxin Wang, et al. “A Mesoscale Connectome of the Mouse Brain.” Nature 508, no. 7495 (April 10, 2014): 207–14.

  • Vélez-Fort, Mateo, Charly V. Rousseau, Christian J. Niedworok, Ian R. Wickersham, Ede A. Rancz, Alexander P. Y. Brown, Molly Strom, and Troy W. Margrie. “The Stimulus Selectivity and Connectivity of Layer Six Principal Cells Reveals Cortical Microcircuits Underlying Visual Processing.” Neuron 83, no. 6 (September 17, 2014): 1431–43.

  • Feng, David, Chris Lau, Lydia Ng, Yang Li, Leonard Kuan, Susan M. Sunkin, Chinh Dang, and Michael Hawrylycz. “Exploration and Visualization of Connectivity in the Adult Mouse Brain.” Methods, Spatial mapping of multi-modal data in neuroscience, 73 (February 2015): 90–97. 

  • Kim, Yongsoo, Kannan Umadevi Venkataraju, Kith Pradhan, Carolin Mende, Julian Taranda, Srinivas C. Turaga, Ignacio Arganda-Carreras, et al. “Mapping Social Behavior-Induced Brain Activation at Cellular Resolution in the Mouse.” Cell Reports 10, no. 2 (January 13, 2015): 292–305. 

  • Vousden, Dulcie A., Jonathan Epp, Hiroyuki Okuno, Brian J. Nieman, Matthijs van Eede, Jun Dazai, Timothy Ragan, et al. “Whole-Brain Mapping of Behaviourally Induced Neural Activation in Mice.” Brain Structure and Function, (April 24, 2014): 1–15.

  • Ragan, T., Kadiri, L.R., Venkataraju, K.U., Bahlmann, K., Sutin, J., Taranda, J., Arganda-Carreras, I., Kim, Y., Seung, H.S., and Osten, P. Serial two-photon tomography: an automated method for ex-vivo mouse brain imaging. Nature Methods, 2012.

  • Ragan, T., et al., High-resolution whole organ imaging using two-photon tissue cytometry. Journal of Biomedical Optics, 2007. 12(1): p. 014015.

  • Gleave, Jacqueline A., Jason P. Lerch, R. Mark Henkelman, and Brian J. Nieman. “A Method for 3D Immunostaining and Optical Imaging of the Mouse Brain Demonstrated in Neural Progenitor Cells.” PLoS ONE 8, no. 8 (August 6, 2013):

  • Kim, K.H., et al., Three-dimensional tissue cytometer based on high-speed multiphoton microscopy. Cytometry. Part A : The Journal of the International Society for Analytical Cytology, 2007. 71(12): p. 991-1002.

  • Bahlmann, K., et al., Multifocal multiphoton microscopy (MMM) at a frame rate beyond 600 Hz. Optics Express, 2007. 15(17): p. 10991-10998.