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WHOLE TISSUE IMAGING AND ANALYSIS

Biodistrubtion

CONTROLLED TISSUE DISTRIBUTION FROM VIRAL GENE TRANSFER VECTORS IS KEY TO THE VIABILITY OF GENE THERAPY.

Vector transduction efficiency assayed across entire organ systems.

We can quickly provide quantitative measures of vector transduction efficiency across entire organs with subcellular resolution.

 

Gene therapy has recently undergone a renaissance with the advent of specialized molecular biological techniques used to generate disease specific reagents. Controlled tissue distribution and expression from gene transfer vectors is essential for the utility of a viable therapeutic for gene therapy.  As such, it's important to screen viral serotypes across a range of properties pertaining to antigenicity, in vivo tropism and receptor interactions, all of which can play a major role in determining the regional and cellular transduction efficiencies of viral vector strains across different mammalian organs.

Through our imaging and analysis services, we can provide a global and regional definition of the pattern of vector infection and expression throughout an organ. Recovered tissue sections can also undergo secondary analysis to characterize specific molecular signatures and targets. In addition to screening the primary organ of interest, we can also screen additional organs (liver, heart, spleen, etc.) from the same animal to quantify potential off-target effects.